Biomarkers Platform

Dr. Don Sin

Platform Leader: Dr. Don Sin

 

 

 

 

 

 

 

Goals

  • To determine novel molecular targets of airway disease as a foundation for biomarker discovery.
  • To use emerging genomics and proteomics tools to better phenotype cohorts and to develop novel biomarkers to predict development and progression of chronic airway diseases.

Publications

Should COPD stand for “Comorbidities-related Obstructive Pulmonary Disease”?
Sin DD. Should COPD stand for “Comorbidities-related Obstructive Pulmonary Disease”? European Respiratory Journal 2015;46:901-2.

Molecular mechanisms underlying variations in lung function: a systems genetics analysis
Obeidat M, Hao K, Bossé Y, Nickle DC, Nie Y, Postma DS, Laviolette M, Sandford AJ, Daley DD, Hogg JC, Elliott WM, Fishbane N, Timens W, Hysi PG, Kaprio J, Wilson JF, Hui J, Rawal R, Schulz H, Stubbe B, Hayward C, Polasek O, Järvelin MR, Zhao JH, Jarvis D, Kähönen M, Franceschini N, North KE, Loth DW, Brusselle GG, Smith AV, Gudnason V, Bartz TM, Wilk JB, O'Connor GT, Cassano PA, Tang W, Wain LV, Artigas MS, Gharib SA, Strachan DP, Sin DD, Tobin MD, London SJ, Hall IP, Paré PD. Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respiratory Medicine 2015;3:782-95

The relationship between helicobacteri pylori seropositivity and chronic obstructive pulmonary
Sze MA, Chen YR, Tam S, Tashkin D, Wise RA, Connett JE, Man SFP, Sin DD. The relationship between helicobacteri pylori seropositivity and chronic obstructive pulmonary disease. Thorax 2015;70:923-9.

Serum bilirubin and disease progression in mild chronic obstructive pulmonary disease
Apperley S, Park HY, Holmes DT, Man SFP, Tashkin D, Wise RA, Connett JE, Sin DD. Serum bilirubin and disease progression in mild chronic obstructive pulmonary disease. Chest  2015;148:169-75

Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease
Liu JC, Leung JM, Ngan DA, Nashta NF, Guillemi S, Harris M, Lima VD, Um SJ, Li Y, Tam S, Shaipanich T, Raju R, Hague C, Leipsic JA, Bourbeau J, Tan WC, Harrigan PR, Sin DD, Montaner J, Man SFP. Absolute leukocyte telomere length in HIV-infected and uninfected individuals: evidence of accelerated cell senescence in HIV-associated chronic obstructive pulmonary disease. Plos One 2015;10:e0124426.