Airway Imaging Platform

Platform Leader: Dr. Grace Parraga

 

 

 

 

 

 

 

 

Team Members:

Dr. Stephen Beyea
Dr. Anurag Bhalla
Dr. Harvey Coxson
Dr. Miranda Kirby

Dr. Jonathan Leipsic
Dr. Mike Noseworthy
Dr. Alexei Ouriadov
Dr. Will Reisman
Dr. Sarah Svenningsen
Dante Capaldi
Robert DiCesare
Rachel Eddy
Fumin Guio
Eric Lessard
Damien Pike
Khadija Sheikh
Ryan Yip

 

 

 

 Goals

  • To expand use of novel CT and MRI for COPD patient phenotypes to 4 or 5 geographical nodes in Canada
  • To enable novel pulmonary imaging platforms across CRRN nodes and investigators for future studies (ex. proof of concept RCTs of novel therapies in asthma, CF or COPD).

Publications

Oscillatory Positive Expiratory Pressure in Chronic Obstructive Pulmonary Disease
S Svenningsen, GA Paulin, K Sheikh, F Guo, A Hasany, M Kirby, R Etemad-Rezai, DG McCormack and G Parraga. Oscillatory Positive Expiratory Pressure in Chronic Obstructive Pulmonary Disease. Journal of Chronic Obstructive Lung Disease: COPD, 2015 Oct 2:1-9 DOI: 10.3109/15412555.2015.1043523

Non-Invasive Quantification of Alveolar Morphology in elderly never- and ex-smokers
GA Paulin, A Ouriadov, E Lessard, K Sheikh, DG McCormack and G Parraga. Non-Invasive Quantification of Alveolar Morphology in elderly never- and ex-smokers. Physiol Rep, 3 (9), 2015, e12583,doi: 10.14814/phy2.12583.

This is What COPD Looks Like
K Sheikh, HO Coxson and G Parraga. This is What COPD Looks Like. Respirology (2015) August 26 2015 doi: 10.1111/resp.12611 Epub ahead of print.

Ventilation Heterogeneity in Ex-smokers without Airflow Limitation
D Pike, M Kirby, F Guo, DG McCormack and G Parraga. Ventilation Heterogeneity in Ex-smokers without Airflow Limitation Acad Radiol. 2015 Aug;22(8):1068-78. doi: 10.1016/j.acra.2015.04.006. Epub 2015 May 23.2015.

Pulmonary CT and MRI that help explain COPD Pathophysiology and Outcomes
E.A. Hoffman, D.A. Lynch, R.G. Barr, E.J.R. van Beek, and G. Parraga. Pulmonary CT and MRI that help explain COPD Pathophysiology and Outcomes.  J Magn Reson Imaging. 2015 Jul 22. doi: 10.1002/jmri.25010. [Epub ahead of print].

COPD: Do Imaging Measurements of Emphysema and Airway Disease Explain Symptoms and Exercise Capacity?
M Kirby, D Pike, DD Sin, HO Coxson, DG McCormack, and G Parraga. COPD: Do Imaging Measurements of Emphysema and Airway Disease Explain Symptoms and Exercise Capacity? Radiology. 2015 Jul 7:150037. [Epub ahead of print].

Globally Optimal co-Segmentation of Three-dimensional Pulmonary 1H and hyperpolarized 3He MRI with spatial consistence prior
F Guo, J Yuan, M Rajchl, S Svenningsen, DPI Capaldi, K Sheikh, A Fenster and G Parraga. Globally Optimal co-Segmentation of Three-dimensional Pulmonary 1H and hyperpolarized 3He MRI with spatial consistence prior. Med Image Anal 2015 Jul;23(1):43-55. doi: 10.1016/j.media.2015.04.001. Epub 2015 Apr 17.

Differences Hyperpolarized 3He Ventilation Imaging after 4 years in adults with Cystic Fibrosis
G Paulin, S Svenningsen, BN Jobse,S. Mohan, M Kirby, JF Lewis, and G Parraga. Differences Hyperpolarized 3He Ventilation Imaging after 4 years in adults with Cystic Fibrosis  J Magn Reson Imaging. 2015 Jun;41(6):1701-7. doi: 10.1002/jmri.24744. Epub 2014 Aug 30.

Ultra-short echo-time pulmonary MRI: Evaluation and reproducibility in COPD subjects with and without bronchiectasis
W Ma, K Sheikh, S Svenningsen, D Pike, F Guo*, R Etemad-Rezai, J  Leipsic, HO Coxson, DG McCormack and G Parraga. Ultra-short echo-time pulmonary MRI: Evaluation and reproducibility in COPD subjects with and without bronchiectasis. 2015 May;41(5):1465-74. doi: 10.1002/jmri.24680. Epub 2014 Jun 26.

Free-breathing Pulmonary and 3He MRI: Comparison in COPD and Bronchiectasis
DPI Capaldi, K Sheikh, F Guo, S Svenningsen, R Etemad-Rezai, HO Coxson, JA Leipsic, DG McCormack and G Parraga.  Free-breathing Pulmonary and 3He MRI: Comparison in COPD and Bronchiectasis Acad Radiol. 2015 Mar;22(3):320-9. doi: 10.1016/j.acra.2014.10.003. Epub 2014 Dec 6

Pulmonary Imaging Abnormalities in an Adult Case of Congenital Lobar Emphysema
D Pike, S Mohan, W Ma, JF Lewis and G Parraga.  Pulmonary Imaging Abnormalities in an Adult Case of Congenital Lobar Emphysema J Radiol Case Rep. 2015.Feb 28;9(2):9-15. 10.3941/jrcr.v912.2048. eCollection.

Pulmonary Artery Abnormalities in Ex-smokers with and without Airflow Limitation
TJ Lindenmaier, M Kirby, GA Paulin, L Mielniczuk, IA Cunningham, M Mura, C Licskai, and G Parraga. Pulmonary Artery Abnormalities in Ex-smokers with and without Airflow Limitation. J COPD.  COPD, 0 : 1 – 11 , 2015. 1541-2555 print / 1541-2563 online DOI: 10.3109/15412555.2015.1074666.

Pulmonary Functional Magnetic Resonance Imaging: Asthma Temporal-spatial Maps
S. Svenningsen, F Guo, M. Kirby, S. Choy, A Wheatley, DG. McCormack and G. Parraga. Pulmonary Functional Magnetic Resonance Imaging: Asthma Temporal-spatial Maps Acad Radiol. 2014 Nov;21(11):1402-10. doi: 10.1016/j.acra.2014.08.002.

What are ventilation defects in healthy elderly never-smokers?
K Sheikh, G Paulin, D Pike, S Svenningsen, NAM Paterson DG McCormack and G Parraga. What are ventilation defects in healthy elderly never-smokers? J Appl Physiol (1985). 2014 Aug 1;117(3):297-306. doi: 10.1152/japplphysiol.00046.2014. Epub 2014 Jun 5.

Hyperpolarized 3He and 129Xe MRI ADC: Physiological relevance in older never- and ex-smokers
M. Kirby, A Ouriadov, S Svenningsen, A Owrangi*, A Wheatley, R Etemad-Rezai, GE Santyr, DG McCormack and G Parraga. Hyperpolarized 3He and 129Xe MRI ADC: Physiological relevance in older never- and ex-smokers. Physiol Rep. 2014 Jul 16;2(7). pii: e12068. doi: 10.14814/phy2.12068.

Using Pulmonary Imaging to Move COPD Beyond FEV1
HO Coxson, J Leipsic, G Parraga and DD Sin. Using Pulmonary Imaging to Move COPD Beyond FEV1.  Am J Resp Crit Care Med. 2014 Jul 15;190(2):135-44. doi: 10.1164/rccm.201402-0256PP. Review.

Book Chapters

The Role of Magnetic Resonance Imaging in the Evaluation of Respiratory Disease
M. Kirby, HO Coxson and G Parraga. The Role of Magnetic Resonance Imaging in the Evaluation of Respiratory Disease. In Diagnostic Evaluation of the Respiratory System. Jaypee Brothers Medical Publishers JP Medical Ltd London SW1H 0HW UK info@jpmedpub.com www.jpmedpub.com 2015 Editor Claudio Sorino.