Basic Science and Discovery Platform

Dr. Andrew Halayko

 

Platform Leader: Dr. Andrew Halayko

 

 

 

 

Team Members:

Dr. Michel Aliani
Dr. Carolyn Baglole
Dr. Yohan Bosse
Dr. Christopher Carlsten
Dr. James Davie
Dr. Gail Gauvreau
Dr. Richard Leigh
Dr. Neeloffer Mokherjee
Dr. Paul O’Byrne
Dr. David Proud
Dr. Amir Ravandi
Dr. Martin Stampfli
Dr. John Wilkins
Aruni Jha

Goals

  • To identify markers and mechanisms of disease origin and progression that can be targets for novel drug and biomarker discovery for future pre-clinical studies and network clinical trials
  • interrogate biological specimens from human subjects in current cohorts for comprehensive molecular characterization.

Publications

Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma.
Piyadasa H, Altieri A, Basu S, Schwartz J, Halayko AJ, Mookherjee N. Biosignature for airway inflammation in a house dust mite-challenged murine model of allergic asthma. Biol Open. 2016 Jan 6;5(2):112-21. doi: 10.1242/bio.014464.

Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice
Morissette MC, Shen P, Thayaparan D, Stämpfli MR. Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice. Eur Respir J. 46(5):1451-1460 2015.