Physiology Platform

Platform Leader: Dr. Denis O'Donnell

Team Members: 

Dr. Jordan Guenette
Dr. Dennis Jensen
Dr. Geoff Maksym
Dr. François Maltais
Dr. Darcy Marciniuk
Dr. Alberto Neder
Dr. Mike Stickland
Kathy Webb, M.Sc.

Goals

  • To identify the most sensitive test(s) of peripheral airway dysfunction for earlier diagnosis and more accurate prognosis of smokers and non-smokers who are susceptible to airway injury.
  • To support the other CRRN platforms by providing a comprehensive physiological characterization and phenotyping of small airway dysfunction.

Publications

Pulmonary gas exchange abnormalities in mild COPD: implications for exercise intolerance
Elbehairy AF, Ciavaglia CE, Webb KA, Guenette JA, Jensen D, Mourad SM, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Pulmonary gas exchange abnormalities in mild COPD: implications for exercise intolerance. Am J Respir Crit Care Med published online March 31, 2015 as doi: 10.1164/rccm.201501-0157OC.

Effect of age-related ventilatory inefficiency on respiratory sensation during exercise
Faisal A, Webb KA, Guenette JA, Jensen D, Neder JA, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Effect of age-related ventilatory inefficiency on respiratory sensation during exercise. Respir Physiol Neurobiol 2015; 205: 129-139. [doi:10.1016/j.resp.2014.10.017]

Physiological characterization of the chronic bronchitis phenotype in GOLD grade 1B COPD
Elbehairy A, Raghavan N, Cheng S, Yang L, Webb KA, Neder JA, Guenette JA, Mahmoud MI, O’Donnell DE; on behalf of the Canadian Respiratory Research Network. Physiological characterization of the chronic bronchitis phenotype in GOLD grade 1B COPD. Chest published online November 13, 2014 as doi: 10.1378/chest.14-1491.